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Metformin and the ATM DNA damage response

related results about 50.

Evaulating the role of metformin on DNA damage and DNA ...

EVALUATING THE ROLE OF METFORMIN ON DNA DAMAGE AND DNA DAMAGE RESPONSE IN OVARIAN CANCER . By Timothea Konstantinou . A thesis submitted to the University of Birmingham for the degree of MRes in Cancer
http://etheses.bham.ac.uk/5376/1/Konstantinou14MRes.pdf

and the ATM DNA damage response (DDR): the onset …

1 Δ Abstract: agonist intrinsic sweeper Warburg in life Research Perspective Metformin and the ATM DNA damage response (DDR): Accelerating
https://pdfs.semanticscholar.org/83ec/93c93e67c029810f8dda17d145ce...

Metformin enhances radiation

Metformin could augment IR induced DNA damage response, as metformin facilitated IR achieving a higher level expression of γ-H2AX at 4 h after radiation and delaying the disappearance of γ-H2AX expression accompanied with the activation of ATM in our study. γ-H2AX plays an essential role in the repair of the breaks in response to DNA damage ...
https://www.sciencedirect.com/science/article/pii/S0753332214001826

Metformin and the ATM DNA damage

15/07/2016 · Metformin and the ATM DNA damage response (DDR): Accelerating the onset of stress-induced senescence to boost protection against cancer. Javier A. Menendez, Sílvia Cufí, Cristina Oliveras-Ferraros, Begoña Martin-Castillo, Jorge Joven, Luciano Vellon, Alejandro Vazquez-Martin
https://www.semanticscholar.org/paper/Metformin-and-the-ATM-DNA...

Metformin activates an Ataxia Telangiectasia Mutated (ATM ...

CreB, β-catenin and Chk2 phospho-status in response to metformin treatment are indicated by dashed circles. (B and C) immunofluorescence for (B and C) immunofluorescence for phospho-γh2AXSer139, 53BP1 and phospho-AtMSer1981 in A431 epidermoid tumor cells, either untreated or treated with 5 mmol/L metformin for …
http://www.tandfonline.com/doi/pdf/10.4161/cc.10.9.15423

Metformin and the ATM DNA damage

By activating the ataxia telangiectasia mutated (ATM)-mediated DNA Damage Response (DDR), the AMPK agonist metformin might sensitize cells against further damage, thus mimicking the precancerous stimulus that induces an …
http://europepmc.org/articles/PMC3249452

Metformin activates an Ataxia

Metformin activates an Ataxia Telangiectasia Mutated (ATM)/Chk2-regulated DNA damage-like response
http://www.tandfonline.com/doi/abs/10.4161/cc.10.9.15423

ATM ATM serine/threonine kinase [ …

29/01/2017 · ATM, a gene known to be involved in DNA repair and cell cycle control, plays a role in the effect of metformin upstream of AMP-activated protein kinase, and variation in this gene alters glycemic response to metformin
https://www.ncbi.nlm.nih.gov/gene/472

(PDF) Metformin lowers the threshold …

19/06/2011 · Metformin significantly enhanced the number of MEFs entering a senescent stage in response to doxorubicin, an anthracycline that induces cell senescence by activating DNA damage signaling pathways (e.g., ATM/ATR) in a reactive oxygen species (ROS)-dependent manner. Using WI-38 and BJ-1 human diploid …
https://www.researchgate.net/publication/221853450_Metformin...

Metformin: Prevention of genomic …

Metformin stimulates the DNA damage response (DDR) in the homologous end-joining, homologous recombination, and nucleotide excision repair pathways. This review focuses on the protective properties of metformin against genomic instability.
https://www.sciencedirect.com/science/article/pii/S1383571817303108